The Primary Information of Tandem Pore Domain Potassium Channel (K2P)
1. Summary
The two-pore-domain or tandem pore domain potassium channels (K2P) are a family of 15 members (K2p1.1, K2p2.1, K2p3.1, K2p4.1, K2p5.1, K2p6.1, K2p7.1, K2p9.1, K2p10.1, K2p12.1, K2p13.1, K2p15.1, K2p16.1, K2p17.1, K2p18.1) that form what is known as leak channels which possess Goldman-Hodgkin-Katz (open) rectification [1].
2. Binding Sites
Ruthenium red binds to the residues (D135 (red sphere) in TREK-2 [2] and E70 (yellow sphere) in TASK-3 [3]) lining the wall of the extracellular ion pathway to inhibit TREK-2 and TASK-3. Mutations of the residues A35, E38 and V42 (black sphere) within the binding site in the extracellular cap of TRAAK significantly increased the TKDC-induced inhibition, indicating that the proposed site was involved in modulating channels. [4] Central cartoon shows the locations of structurally defined K2P small molecule binding sites including the Keystone inhibitor site (white sphere) [5], K2P modulator pocket (grey)[6], Fenestration site (green sphere) [7], Modulatory lipid site (Orange sphere) [8], and Vestibule site (blue) [9].
3. Target List
| ICDB_Pro ID | Protein Name | Organism | Uniport Accession Number | Gene Name |
|---|---|---|---|---|
| ICDB_Pro_1513 | Potassium channel subfamily K member 12 | Homo sapiens (Human) | Q9HB15 | KCNK12 |
| ICDB_Pro_1294 | Potassium channel subfamily K member 13 | Mus musculus (Mouse) | Q8R1P5 | Kcnk13; Gm1570 |
| ICDB_Pro_1482 | Potassium channel subfamily K member 13 | Rattus norvegicus (Rat) | Q9ERS0 | Kcnk13 |
| ICDB_Pro_1512 | Potassium channel subfamily K member 13 | Homo sapiens (Human) | Q9HB14 | KCNK13 |
| ICDB_Pro_1308 | Potassium channel subfamily K member 15 | Rattus norvegicus (Rat) | Q8R5I0 | Kcnk15; Task5 |
| ICDB_Pro_1509 | Potassium channel subfamily K member 15 | Homo sapiens (Human) | Q9H427 | KCNK15; TASK5 |
| ICDB_Pro_1413 | Potassium channel subfamily K member 16 | Homo sapiens (Human) | Q96T55 | KCNK16; TALK1 |
| ICDB_Pro_1412 | Potassium channel subfamily K member 17 | Homo sapiens (Human) | Q96T54 | KCNK17; TALK2; TASK4; UNQ5816/PRO19634 |
| ICDB_Pro_1104 | Potassium channel subfamily K member 18 | Rattus norvegicus (Rat) | Q6Q1P3 | Kcnk18; Tresk-2; Tresk2 |
| ICDB_Pro_1120 | Potassium channel subfamily K member 18 | Mus musculus (Mouse) | Q6VV64 | Kcnk18; Tresk-2; Tresk2 |